The Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extract
Abstract
Purpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats.
Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes.
Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage
Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats.
Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Jatmiko Susilo, Siswanta Jaka Purnama, Ardianti Wahyuni, Bambang Purwanto, Muchsin Doewes, Dono Indarto
This work is licensed under a Creative Commons Attribution 4.0 International License.