Role of TNF-α in Diabetic Ulcer Healing Process

Abstract

One of the long-term complications of diabetes mellitus is diabetic ulcers (15%) and 85% of the cases are the cause of amputation on patients with diabetes mellitus. Diabetic foot ulcers increase apoptosis and decrease fibroblast proliferation of fibroblasts and inflammatory reactions is elongated, this is as evidenced by the presence of neutrophil granulocytes in large quantities in the wound. Neutrophil granulocytes secrete pro-inflammatory cytokines mainly TNF-α. TNF-α is causing wound healing becomes disconnected and uncoordinated. This paper discussed the role of TNF-α in diabetic foot ulcers.